Hoʻolaha ʻo Hangzhou New-Test i ka Epoch-making Pet Diagnostic New Product - Canine and Feline Renal Function 3-in-1 combo Test Kit
Ua hoʻolaha kūkala ʻo Hangzhou New-Test Biotechnology Co., Ltd. i ka hoʻokuʻu ʻia ʻana o ʻelua mau huahana diagnostic holoholona hou i ka mākeke immuno-diagnostic holoholona holoholona: ka Canine/Feline renal function Triple Test Kit (Creatinine/SDMA/CysC Triple Test) (Fig. 1 a me Fig. 2), e lawe mai i kahi hoʻonā hou a pololei i nā diagnostics olakino olakino a me ka mālama ʻana.
Kiʻi 1 Kiʻi hoʻāʻo ʻekolu o ka hana ʻāʻī Canine Kiʻi 2 Kiki hoʻāʻo ʻekolu o ka Feline renal function.
I ʻOkakopa 2022, ʻo New-Test Biotechnology Co., Ltd. ka mea mua i hoʻokumu i ka honua multi-channel multiplex fluorescence immunoassay analyser, NTIMM4 (ke kolu o ka hanauna, e ʻike i ke Kiʻi 3), a i ka makahiki 2024, ka immunofluorescence multi-channel multiplex hou. mea anaana, NTIMM2 (hanauna eha, nana Kii 4). ʻO ka pahu hoʻāʻo hui pū 3-i-1 hou loa he kūpono me nā hiʻohiʻona ʻelua.
Kii 3 NTIMM4 Kii 4 NTIMM2
ʻO ka hana kūikawā i ka noiʻi a me ka hoʻomohala ʻana o ka mole liʻiliʻi no ʻeono makahiki, ua hoʻokuʻu ʻia nā huahana hou.
ʻO ka pololei o ka ʻike mole liʻiliʻi he mea paʻakikī ia e lanakila ai ma ke kahua o ka hoʻāʻo POCT, a ʻo ia hoʻi ke kuhikuhi o ka noiʻi a me ka hoʻomohala ʻana i hoʻolaʻa ʻia ʻo Nest-Test Bio mai kona hoʻokumu ʻia ʻana ma mua o 6 mau makahiki i hala. ʻO nā hiʻohiʻona hoʻopau kino a palaho o nā mea fluorescent kuʻuna e pili pono i ka pololei o nā hopena ʻike mole liʻiliʻi. Rare-earth nanocrystal labeling technology, the fourth generation of fluorescent nanomaterials developed by New-Test, ua ʻike ʻia ʻo ia ka mea paʻa loa i nā nanomaterial fluorescent i ka mākeke, nona ka pono o ka lanakila ʻana i nā hiʻohiʻona kino o ke kinai māmā. Hoʻohui pū ʻia me nā makahiki he nui o ka hoʻomau ʻana i ke kaʻina hana, ua hoʻopau hope ia i ka pilikia o ka honua holoʻokoʻa o ka maikaʻi ʻole i ka hoʻāʻo ʻana o ka mole liʻiliʻi POCT. ʻO ka pahu mua, ʻo ia ka pahu hoʻāʻo triple function kidney. Hōʻoiaʻiʻo ia i ka pololei a me ka paʻa o nā molekole liʻiliʻi ʻelua (creatinine & SDMA) ʻike reagents i loko o kahi manawa mana 2-makahiki.
“Loaʻa ka hoʻāʻo hoʻokahi, no ke aha e hoʻomohala ai i kahi triad hana renal”——Ka hope o ka hooulu ana o ka hana renal triad
I kēia manawa, ʻo nā hōʻailona maʻamau o ka hana maʻamau maʻamau i loko o nā ʻīlio a me nā pōpoki ʻo ia ka creatinine (CREA) a me ka urea nitrogen i ka biochemistry; ʻO CysC (cystatin C) a me ka symmetric dimethylarginine (SDMA) i nā hōʻailona palekana, a pēlā aku. I ka emi ʻana o ka helu kānana glomerular ma muli o ka hōʻeha ʻeha, e hōʻiliʻili kēia mau hōʻailona i loko o ke koko a hoʻonui i ka noʻonoʻo, no laila e hōʻike ana i ke kiʻekiʻe o ka hana renal. Hoʻokaʻawale ka International Society for Research in Kidney Diseases (IRIS) i ka hōʻino ʻana o ka renal i nā pōpoki i ʻehā mau māka e pili ana i ka waiwai o ka creatinine (Papa I, maʻamau a ʻoluʻolu paha: <1.6 mg/dL; Papa II, haʻahaʻa: 1.6-2.8 mg. /dL; Papa III, ko'iko'i: 2.8-5.0 mg/dL a me ka Papa IV, ka pae hope: >5.0; mg/dL).
Hoʻokaʻawale ʻia ka hōʻino ʻana o ka renal i nā ʻīlio i ʻehā mau papa (Papa I, maʻamau a ʻoluʻolu paha: <1.4 mg/dL: Papa II, haʻahaʻa: 1.4-2.0 mg/dL: Papa III, koʻikoʻi: 2.0-4.0 mg/dL: Papa IV, a me ka pae hope: >4.0 mg/dL). Eia nō naʻe, ma muli o ka liʻiliʻi o ka naʻau o ka creatinine i ka maʻi maʻi maʻi maʻi maʻi (CKD), ua hoʻohana ʻia kekahi hōʻailona mua o ka kānana hana nephron, "symmetric dimethylarginine (SDMA)". Wahi a ka ʻikepili, hiki i ka SDMA ke hōʻike i nā mea ʻino ma 25-40% o ka hōʻino ʻana i ka renal, aʻo ka creatinine ka mea maʻamau i manaʻo ʻia he ʻano maʻamau ma 75% o ka hōʻino.
ʻO CysC (cystatin C) he mea hoʻopaʻapaʻa protease cysteine, he paona molekala haʻahaʻa (13.3 kD), ʻaʻole-glycosylated kumu protein. ʻO ia kekahi o nā hōʻailona hoʻohana nui ʻia o ka hana renal mua i ka lāʻau lapaʻau kanaka. E like me ka creatinine a me SDMA, ua kānana ʻia ia ma o ka glomerulus, akā ʻokoʻa mai ka creatinine a me SDMA no ka mea ʻaʻole ma o ka ʻāpana urinary kona metabolism, akā aneane pau loa i ka metabolized e ka reabsorption ma o nā tubules renal. ʻAʻole i ʻike mua ʻia, e alakaʻi ana i nā loea he nui, nā loea a me nā palapala i ʻelua manaʻo manaʻo like ʻole e pili ana i ka hōʻeha maʻi maʻi i loko o nā pōpoki: manaʻo kekahi ʻo CysC ʻO ka hōʻailona o ka hōʻeha maʻi maʻi i hiki ke hoʻohana ʻia i nā ʻīlio a me nā pōpoki, aʻo nā mea ʻē aʻe e manaʻoʻiʻo ua hoʻopili maikaʻi ʻo CysC i ka CKD canine, akā maikaʻi ʻole i nā pōpoki.
No ke aha he ʻelua mau manaʻo hoʻoholo like ʻole mai ka "glomerular filtration function index" like?
ʻO Anuria ke kumu, ʻo ia kahi maʻi i ʻoi aku ka nui o nā pōpoki ma mua o nā ʻano ʻē aʻe, ʻoi aku hoʻi i nā pōpoki kāne. Hōʻike kekahi mau ʻikepili i ka ulu ʻana o Anuria i nā pōpoki kāne e like me 68.6%, a ʻo Anuria e hopena pololei i ka obstruction o ka excretion o creatinine, koko urea nitrogen a me SDMA. Ke hoʻololi mau nei ke kino a hana i ka creatinine hou, ke koko urea nitrogen a me SDMA, i ka wā e ʻike ai i nā hōʻailona ʻekolu i loko o ke koko i kēia manawa, e piʻi nui ana a i ʻole ka pohā o nā hōʻailona inā ʻaʻole i pōʻino maoli ka glomerulus.
Loaʻa i ka CysC kona waiwai kūʻokoʻa i kēia manawa, ʻoiai ʻo kēia hōʻailona he kānana glomerular, ʻaʻole ia e hoʻololi ʻia e ka mimi, aia ma o ka tubular no ka reabsorption. Ke hiki mai ʻo Anuria akā maʻamau ka hana renal, hiki ke mālama ʻia ka helu CysC ma kahi pae maʻamau. Aia wale nō ka pōʻino o ka glomerulus a i ʻole tubular, e hoʻokiʻekiʻe ʻia ka helu helu CysC i mea ʻino. No laila, hiki i ka ʻike ʻana i nā ʻōlelo kuhikuhi ʻekolu ke hana i ka hōʻoia pololei a hāʻawi i ka lāʻau kūpono i ʻoi aku ka wikiwiki a me ka maikaʻi.
Hāʻawi nā pahu hoʻāʻo 3-i-1 hou i ka hōʻailona hōʻoia hou i ka ʻike ʻana i ka ʻeha renal i nā ʻīlio a me nā pōpoki!
ʻO ka wehewehe ʻana i nā loina a me ka hui pū ʻana me nā hiʻohiʻona o nā hōʻailona, ua hānau ʻia ka New-Test renal function marker 3-in-1 test kits me kahi koʻikoʻi koʻikoʻi no nā ʻīlio a me nā pōpoki (ʻoi aku nā pōpoki) me Anuria:
Hoʻohana ʻia nā pahu hoʻāʻo 3-in-1 hou-Test renal function no ka ʻike ʻana inā he ʻeha maoli ka hana renal i ke kūlana Anuria a i ʻole ka hopena o ka hoʻokiʻekiʻe ʻana o nā indexes ma muli o Anuria. ʻO ka hōʻeha ʻana i ka hana renal pono wale nō ka catheterization mimi a me ka mālama pili, a ʻoi aku ka maikaʻi o ka prognosis. ʻAʻole pono ka hoʻokiʻekiʻe ʻana o nā indexes i ka urinary catheterization a me ka lāʻau anti-inflammatory, akā pili pū kekahi me ka maʻi renal, a ʻoi aku ka pilikia o ka prognosis, a hiki ke lilo i maʻi maʻi maʻi.
Ma lalo iho nei ka New-Test renal function marker 3-in-1 test kits data no typical Anuria (Non-real kidney injury) and Anuria + kidney injury in New-Test clinical research cases:
| ʻIke anuria Hōʻailona hana renal hōʻike hou 3-i-1 pahu hoʻāʻo | Papahana | Ka hopena | Ka hopena |
| Creatinine | + | + | |
| SDMA | + | + | |
| CysC | + | - | |
| Ka hopena | ʻO Anuria ka hopena i ka ʻeha renal | ʻO ka pae mua o Anuria a me ka hōʻeha renal a i ʻole Anuria i hiki ʻole i ka hōʻeha renal |
Aia ma lalo iho kahi ʻāpana o ka ʻikepili lapaʻau maʻamau a me ka wehewehe hihia o ka New-Test renal function 3-in-1 kit hoʻāʻo:
| Cat | Moolelo Lapaau | Hōʻailona hōʻailona | CysC(mg/L) | SDHA (ug/dL) | CR(mg/dL) | Ka hopena |
| 2024090902 | Cystitis/ʻeha renal ʻeha | ʻO ke kūlana noʻonoʻo maikaʻi ʻole, Nalo i ka ʻai ʻana, ʻAnuria (Chronic renal failure, anuria) | 1.09 | 86.47 | 8.18 | ʻO ka ʻeha ʻeha me Anuria |
| 2024091201 | / | ʻO ke kūlana noʻonoʻo maikaʻi ʻole, Anuria, ʻAʻohe hana renal | 0.51 | 27.44 | 8.21 | ʻAʻohe hōʻeha renal me Anuria/Early stage |
| 2024092702 | / | Anuria | 0.31 | >100.00 | 9.04 | ʻAʻohe hōʻeha renal me Anuria/Early stage |
| 2024103101 | / | Anuria | 0.3 | 14.11 | 6.52 | ʻAʻohe hōʻeha renal me Anuria/Early stage |
| 2024112712 | Anuria | 0.5 | >100.00 | 8.85 | ʻAʻohe hōʻeha renal me Anuria/Early stage | |
| 2024112601 | Dysuria/Anuria | 0.43 | >100.00 | 9.06 | ʻAʻohe hōʻeha renal me Anuria/Early stage | |
| 0.47 | >100.00 | 878 | ʻAʻohe hōʻeha renal me Anuria/Early stage | |||
| 2024112712 | / | Anuria | 0.54 | 94.03 | 8.64 | ʻAʻohe hōʻeha renal me Anuria/Early stage |
Ma ke kūlana o Anuria, ma muli o nā ʻokoʻa i loko o ka mīkini metabolic kūloko o kēlā me kēia index, e loaʻa ka hopena i nā ʻokoʻa nui no ka mea hoʻokahi renal function filtration index. No laila, ʻaʻole pili hou ka hoʻohālikelike ʻana o ka hōʻeha renal o ka creatinine a i ʻole SDMA, a hiki ke loaʻa ka hopena pili kokoke loa ma ka hoʻohui ʻana i ka loiloi me kahi hōʻailona ʻē aʻe "CysC". Manaʻo ʻia e hoʻokumu nā laboratories (hale maʻi) i nā kūlana kūloko e pili ana i ka ʻike lapaʻau, i mea e ʻimi ai i nā mea hou aʻe.
ʻO ka mea hope loa, manaʻolana ʻo New-Test Biotech e hoʻolei aku kēia ʻatikala i kahi pōhaku lepo e huki ai i ka jade, a ke lana nei ka manaʻo o nā mea hana lāʻau lapaʻau lāʻau lapaʻau Kina a me nā mea hana diagnostic reagent e hoʻomohala i nā huahana koʻikoʻi nui a kōkua i nā mea lapaʻau lāʻau lapaʻau kūloko e hiki i ka pae kiʻekiʻe i ka honua!
Pākuʻi: ʻAe ʻia ka palapala palapala palapala no ka pale ʻana i ka waiwai naʻauao
Ka manawa hoʻouna: Jan-22-2025
